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KMID : 0616120060370030190
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Korean Journal of Pharmacognosy
2006 Volume.37 No. 3 p.190 ~ p.195
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Hypolipidemic and Antixidative Effects of Bangpoongtongsungsankamibang on Diet-Induced Obesity Rats
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Jeong Seoung-Hee
Lee Kyung-Tae
Ann Hong-Sik
Lee Jin-Yong
Choi Jong-Won
Kim Deog-Kon
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Abstract
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Obesity is associated with a number of pathological disorders such as non-insulin-dependent diabetes, hypertension, hyperlipidemia, and cardiovascular deseases. Bangpoongtongsungsankamibang(BTSK) has been widely used in the oridental medicine for the treatment of several diseases associated with inflammatory abnormalities in cardiovascular and nervous system. The BTSK is the modified prescription of bangpungtongsungsan in which sea tangle(Laminaria japonica) were added. This study was carried out to detemine the anti-obestic effects of BTSK. Pretreatment with the BTSK at daily dose of 100 or 200 mg/kg (p.o.) for 4 weeks reduced serum triglyceride, total cholesterol contents in rat induced by Poloxamer-407 or Triton WR-1339, respectively. Furthermore, post-treatment with BTSK for four weeks also inhibited body weight gain, adipose tissue mass and hyperlipidemia induced by the high fat diet for six weeks. The BTSK shifted serum total-, HDL- and LDL-cholesterol levels toward the values of normal group, suggesting that BTSK has bypolipidemic effects. The rats fed BTSK reduced lipid group peroxide and hydroxy radical in the rat blood and increased superoxide dismutase (SOD) activity compared to the control group. Taken together, these results support that BTSK improve hyperlipidemia and obesity via the upregulation of anti-oxidative mechanism.
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KEYWORD
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Hyperlipidemia, Obesity, Bangpoongtongsungsankamibang, Anti-oxidative activity, Cholesterol
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